The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2024
Filed:
Aug. 23, 2021
Applicant:
Byondis B.v., Nijmegen, NL;
Inventors:
Gerardus Joseph Andreas Ariaans, Nijmegen, NL;
Rudy Gerardus Elisabeth Coumans, Nijmegen, NL;
Assignee:
Byondis B.V., Nijmegen, NL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61K 9/19 (2006.01); A61K 31/475 (2006.01); C07K 16/30 (2006.01); C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6889 (2017.08); A61K 9/19 (2013.01); A61K 31/475 (2013.01); A61K 47/6803 (2017.08); A61K 47/68031 (2023.08); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); A61K 47/6869 (2017.08); C07K 16/30 (2013.01); C07K 16/40 (2013.01); C12Y 304/17021 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/77 (2013.01);
Abstract
The present invention relates to antibody-drug conjugates (ADCs) wherein a linker drug is site-specifically conjugated to an antibody through an engineered cysteine, and their use as a medicament, notably for the treatment of human solid tumours and haematological malignancies, in particular breast cancer, gastric cancer, colorectal cancer, urothelial cancer, ovarian cancer, uterine cancer, lung cancer, mesothelioma, liver cancer, pancreatic cancer, prostate cancer, and leukaemia.