The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2024
Filed:
Feb. 02, 2022
Applicant:
Mercury Bio, Inc., Santa Fe, NM (US);
Inventors:
Richard Sayre, Los Alamos, NM (US);
Tatiana Vinogradova-Shah, Rochester, NY (US);
Alexander Pertzev, Santa Fe, NM (US);
Assignee:
Mercury Bio, Inc., Santa Fe, NM (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/19 (2006.01); A61K 9/50 (2006.01); A61P 31/14 (2006.01); C07K 14/515 (2006.01); C07K 14/705 (2006.01); C12N 1/18 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2018.01); C12R 1/865 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1131 (2013.01); A61K 9/5068 (2013.01); A61P 31/14 (2018.01); C07K 14/515 (2013.01); C07K 14/705 (2013.01); C12N 1/185 (2021.05); C12N 2310/122 (2013.01); C12R 2001/865 (2021.05);
Abstract
The present invention is directed to-generated extracellular vesicles (EVs) comprising a foreign RNA molecule or protein and at least one foreign membrane surface exposed ligand that specifically binds to a target receptor displayed on a target cell. The present invention also relates to methods of making and using these-generated EVs for targeted gene silencing. The present invention also relates to fusion proteins comprising aextracellular vesicle anchor protein and a second peptide designed to bind to cell-specific receptors.