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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12180263 B1

PDFFull Text
Date of Patent:
Dec. 31, 2024

Filed:

Nov. 06, 2015

Cells lacking b2m surface expression and methods for allogeneic administration of such cells

Applicant:

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

Chad A. Cowan, Boston, MA (US);

Leonardo M. R. Ferreira, Cambridge, MA (US);

Torsten B. Meissner, Somerville, MA (US);

Jack L Strominger, Cambridge, MA (US);

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);

Attorneys:

Morse, Barnes-Brown & Pendleton, P.C.

Lisa M. Warren, Esq.

Erin E. Bryan, Esq.

Primary Examiner:

Anoop K Singh

Int. Cl.
CPC ...
C12N 5/0789 (2010.01); A61K 35/12 (2015.01); A61K 35/28 (2015.01); A61P 31/18 (2006.01); C07K 14/74 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70539 (2013.01); A61K 35/12 (2013.01); A61K 35/28 (2013.01); A61P 31/18 (2018.01); C12N 5/0647 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/1138 (2013.01); A61K 2035/124 (2013.01); A61K 48/0066 (2013.01); C12N 2310/10 (2013.01); C12N 2310/20 (2017.05); C12N 2510/00 (2013.01);
Abstract

Disclosed herein are cells and populations of cells comprising a genome in which the B2M gene has been edited to eliminate surface expression of MHC Class I protein in the cells or population of cells, and methods for allogeneic administration of such cells to reduce the likelihood that the cells will trigger a host immune response when the cells are administered to a subject in need of such cells.

Find Patent Forward Citations

Cowan, Chad. (2024). Cells lacking b2m surface expression and methods for allogeneic administration of such cells (U.S. Patent No. 12180263). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12180263

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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