The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2024
Filed:
Jul. 11, 2019
Applicant:
The Usa, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Inventors:
Anu Puri, Frederick, MD (US);
Mathias Viard, Frederick, MD (US);
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 41/00 (2020.01); A61K 47/54 (2017.01); A61K 47/60 (2017.01);
U.S. Cl.
CPC ...
A61K 9/1271 (2013.01); A61K 41/0071 (2013.01); A61K 47/543 (2017.08); A61K 47/60 (2017.08);
Abstract
Embodiments of vesicles comprising embedded cytotoxic agents are disclosed, as well as methods of making and using the vesicles. Pharmaceutical compositions including the vesicles also are disclosed. The vesicles include a binary lipid bilayer surrounding a cavity, wherein the vesicle binary lipid bilayer includes (i) a non-bilayer forming lipid (or combination of non-bilayer forming lipids) and a PEGylated lipid; and (i) a cytotoxic agent embedded within the vesicle wall.