The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 31, 2024

Filed:

Mar. 11, 2022
Applicant:

Board of Regents, the University of Texas System, Austin, TX (US);

Inventors:

David J. Mangelsdorf, Dallas, TX (US);

Steven A. Kliewer, Dallas, TX (US);

Katie C. Coate, Pelham, AL (US);

Genaro Hernandez, Dallas, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61K 9/00 (2006.01); A61P 1/18 (2006.01); C07K 14/50 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1825 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61P 1/18 (2018.01); C07K 14/50 (2013.01);
Abstract

The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the treatment of EPI or pancreatitis resulting from surgical procedures.


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