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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12178791 B1

PDFFull Text
Date of Patent:
Dec. 31, 2024

Filed:

Aug. 02, 2019

Haloallylamine sulfone derivative inhibitors of lysyl oxidases and uses thereof

Applicant:

Syntara Limited, Frenchs Forest, AU;

Inventors:

Alison Dorothy Findlay, Frenchs Forest, AU;

Craig Ivan Turner, Frenchs Forest, AU;

Mandar Deodhar, Frenchs Forest, AU;

Jonathan Stuart Foot, Frenchs Forests, AU;

Wolfgang Jarolimek, Frenchs Forest, AU;

Wenbin Zhou, Frenchs Forest, AU;

Alberto Buson, Frenchs Forest, AU;

Angelique Elsa Greco, Cammeray, AU;

Assignee:

SYNTARA LIMITED, Frenchs Forest, AU;

Attorney:

Gary J. Gershik

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
C07D 209/08 (2006.01); A61K 31/145 (2006.01); A61K 31/18 (2006.01); A61K 31/4409 (2006.01); A61K 31/47 (2006.01); A61P 17/02 (2006.01); A61P 19/04 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C07C 311/29 (2006.01); C07C 317/32 (2006.01); C07D 213/71 (2006.01); C07D 215/36 (2006.01); C07D 277/64 (2006.01);
U.S. Cl.
CPC ...
A61K 31/18 (2013.01); A61K 31/145 (2013.01); A61K 31/4409 (2013.01); A61K 31/47 (2013.01); A61P 17/02 (2018.01); A61P 19/04 (2018.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C07C 311/29 (2013.01); C07C 317/32 (2013.01); C07D 209/08 (2013.01); C07D 213/71 (2013.01); C07D 215/36 (2013.01); C07D 277/64 (2013.01); C07B 2200/05 (2013.01); C07C 2601/16 (2017.05); C07C 2602/10 (2017.05);
Abstract

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.

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