The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2024
Filed:
Dec. 16, 2019
Ventana Medical Systems, Inc., Tucson, AZ (US);
Pascal Bamford, San Diego, CA (US);
Srinivas Chukka, San Jose, CA (US);
Jim F. Martin, Mountain View, CA (US);
Anindya Sarkar, Sunnyvale, CA (US);
Olcay Sertel, Sunnyvale, CA (US);
Ellen Suzue, Sunnyvale, CA (US);
Harshal Varangaonkar, Belmont, CA (US);
Ventana Medical Systems, Inc., Tucson, AZ (US);
Abstract
A computer-based specimen analyzer () is configured to detect a level of expression of genes in a cell sample by detecting dots that represent differently stained genes and chromosomes in a cell. The color of the stained genes and the chromosomes is enhanced and filtered to produce a dot mask that defines areas in the image that are genes, chromosomes, or non-genetic material. Metrics are determined for the dots and/or pixels in the image of the cell in areas corresponding to the dots. The metrics are fed to a classifier that separates genes from chromosomes. The results of the classifier are counted to estimate the expression level of genes in the tissue samples.