The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2024
Filed:
Mar. 11, 2024
Orna Therapeutics, Inc., Watertown, MA (US);
Ramin Dehghanpoor, Medford, MA (US);
Varun Shivashankar, Cambridge, MA (US);
Orna Therapeutics, Inc., Watertown, MA (US);
Abstract
An apparatus for training a tunable data structure to predict internal ribosome entry site (IRES) activity includes at least a processor and a memory containing instructions configuring the at least a processor to assemble a training set including a plurality of nucleotide sequence data examples IRES sequences and a plurality of correlated observed IRES activity, partition the training set into at least a first section and a second section, train, using the first section at least an activity data structure to generate probable IRES activity using nucleotide sequence data, and iteratively retrain the at least an activity data structure using the second section, wherein each iteration of the iterative retraining includes generating a predicted IRES activity value using the at least an activity neural network and a nucleotide sequence data example, evaluating an error function, and tuning the activity data structure.