The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2024
Filed:
Jun. 11, 2020
Hefei Knature Bio-pharm Co., Ltd., Anhui, CN;
Wei Wang, Anhui, CN;
Kanglin Wang, Anhui, CN;
Minjie Fu, Anhui, CN;
Yonghong Jin, Anhui, CN;
Feng Tian, Anhui, CN;
Heping Jia, Anhui, CN;
Zhihao Hu, Anhui, CN;
HEFEI KNATURE BIO-PHARM CO., LTD., Anhui, CN;
Abstract
The invention discloses a genetically engineered bacterium in which the gene encoding adenine deaminase on the genome of the bacterium is knocked out or/and the gene encoding the enzyme in the NADanabolic pathway is integrated on the genome of the bacterium. The invention also discloses a construction method of the above-mentioned genetically engineered bacteria. The gene encoding adenine deaminase on the genome of the host strain is knocked out to obtain a strain with high NADyield. Or the expression cassettes of the gene encoding the enzyme in the NADsynthesis pathway are constructed separately, and then the enzyme encoding The gene expression cassette is integrated into the genome of the host strain whose gene encoding adenine deaminase is knocked out to construct a strain with high NADproduction. The application of the above genetically engineered bacteria is disclosed. A method of producing NADis disclosed.