The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2024
Filed:
Sep. 23, 2022
Kbio Holdings Limited, London, GB;
Leigh Burden, Owensboro, KY (US);
Steven D. Hume, Owensboro, KY (US);
Joshua Morton, Evansville, IN (US);
Greg Pogue, Austin, TX (US);
Barry Bratcher, Owensboro, KY (US);
Hugh A. Haydon, Louisville, KY (US);
Carrie A. Simpson, Evansville, IN (US);
Nick Partain, Owensboro, KY (US);
John W. Shepherd, Owensboro, KY (US);
KBIO HOLDINGS LIMITED, London, GB;
Abstract
Various embodiments disclosed herein include methods and exemplary compositions associated with conjugation of virus and proteins (e.g., antigen) to form vaccines for delivery of immunological and other therapeutic agents, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; purifying the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances through methodologies described in an exemplary manner, as well as their concentration and collection; and a conjugation platform providing activation of the virus at a pH that increases binding rate and binding propensity between the virus and the protein, wherein embodiments related to the conjugation platform include controlling the ratio of virus to protein.