The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2024
Filed:
Feb. 12, 2018
Applicant:
Genmab B.v., Utrecht, NL;
Inventors:
Frank Beurskens, Utrecht, NL;
Marije Overdijk, Utrecht, NL;
Annieck M. Diks, Gouda, NL;
Rob De Jong, Utrecht, NL;
Kristin Strumane, Werkhoven, NL;
Janine Schuurman, Diemen, NL;
Paul Parren, Odijk, NL;
Assignee:
GENMAB B.V., Utrecht, NL;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 16/10 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); C07K 16/1045 (2013.01); C07K 16/2887 (2013.01); C07K 16/2893 (2013.01); C07K 2317/31 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/72 (2013.01); C07K 2317/734 (2013.01); C07K 2317/75 (2013.01);
Abstract
As described herein are polypeptides and antibodies having an Fc region and an antigen binding region where the Fc region has an Fc-Fc-enhancing mutation and a C1q binding-enhancing mutation providing for polypeptides or antibodies with increased CDC activity and/or agonistic activity.