The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2024
Filed:
Dec. 09, 2019
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Richard S. Blumberg, Weston, MA (US);
Yu-Hwa Huang, Weston, MA (US);
Amit Gandhi, Billerica, MA (US);
Monica Bertagnolli, Newton, MA (US);
Charles Yoon, Brookline, MA (US);
Robert George Edward Holgate, Royston, GB;
Arron Robert Hearn, Ely, GB;
Susan Dana Jones, Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer.