The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2024
Filed:
May. 17, 2022
Scholar Rock, Inc., Cambridge, MA (US);
Thomas Schurpf, Cambridge, MA (US);
Justin W. Jackson, Cambridge, MA (US);
George Coricor, Cambridge, MA (US);
Abhishek Datta, Boston, MA (US);
Stefan Wawersik, Westborough, MA (US);
Christopher Littlefield, Marblehead, MA (US);
Adam Fogel, Watertown, MA (US);
Caitlin Stein, Lebanon, NH (US);
Julia McCreary, Lebanon, NH (US);
Matthew Salotto, Lebanon, NH (US);
Frederick Streich, Jr., Newton, MA (US);
Scholar Rock, Inc., Cambridge, MA (US);
Abstract
Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided.