The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 24, 2024

Filed:

Aug. 17, 2023
Applicant:

Intra-cellular Therapies, Inc., New York, NY (US);

Inventors:

Peng Li, New Milford, NJ (US);

Hailin Zheng, New York, NY (US);

Robert Davis, San Diego, CA (US);

Sharon Mates, New York, NY (US);

Kimberly Vanover, New York, NY (US);

Gretchen Snyder, New York, NY (US);

Assignee:

INTRA-CELLULAR THERAPIES, INC., Bedminster, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4985 (2006.01); A61K 45/06 (2006.01); A61P 1/00 (2006.01); A61P 11/00 (2006.01); A61P 25/36 (2006.01); A61P 29/00 (2006.01); C07D 471/16 (2006.01);
U.S. Cl.
CPC ...
C07D 471/16 (2013.01); A61K 45/06 (2013.01); A61P 1/00 (2018.01); A61P 11/00 (2018.01); A61P 25/36 (2018.01); A61P 29/00 (2018.01);
Abstract

The invention relates to particular prodrugs of substituted heterocycle fused gamma-carbolines, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HTreceptor, the serotonin transporter (SERT), pathways involving the dopamine Dand Dreceptor signaling system, and/or the μ-opioid receptor.


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