The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 24, 2024

Filed:

Oct. 20, 2020
Applicants:

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;

Suzhou Institute of Materia Medica, Jiangsu, CN;

Inventors:

Bing Zhou, Shanghai, CN;

Cheng Luo, Shanghai, CN;

Hualiang Jiang, Shanghai, CN;

Yaxi Yang, Shanghai, CN;

Lianghe Mei, Jiangsu, CN;

Wenchao Lu, Shanghai, CN;

Senhao Xiao, Shanghai, CN;

Shijie Chen, Shanghai, CN;

Shili Wan, Shanghai, CN;

Gang Qiao, Jiangsu, CN;

Rukang Zhang, Shanghai, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/06 (2006.01); C07D 403/06 (2006.01); C07D 403/14 (2006.01); C07D 413/14 (2006.01); C07D 417/06 (2006.01); C07D 471/04 (2006.01); C07D 491/107 (2006.01); C07D 495/04 (2006.01); C07D 495/10 (2006.01); C07D 498/04 (2006.01); C07D 498/10 (2006.01); C07D 513/04 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 413/06 (2013.01); C07D 403/06 (2013.01); C07D 403/14 (2013.01); C07D 413/14 (2013.01); C07D 417/06 (2013.01); C07D 471/04 (2013.01); C07D 491/107 (2013.01); C07D 495/04 (2013.01); C07D 495/10 (2013.01); C07D 498/04 (2013.01); C07D 498/10 (2013.01); C07D 513/04 (2013.01); A61K 45/06 (2013.01);
Abstract

Disclosed is a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by the general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereoisomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising same and use thereof in the treatment of various HAT-related diseases or conditions.


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