The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 24, 2024

Filed:

Sep. 17, 2019
Applicants:

Universite Paris-saclay, Saint-Aubin, FR;

Centre National DE LA Recherche Scientifique, Paris, FR;

Inventors:

Mouad Alami, Bussy Saint Georges, FR;

Abdallah Hamze, Massy, FR;

Olivier Provot, Sartrouville, FR;

Ilhem Khelifi, Le Raincy, FR;

Vincent Blanchard, Pontfaverger Moronvilliers, FR;

Nada Makky-Ibrahim, Massy, FR;

Assignees:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61K 47/54 (2017.01); A61P 35/00 (2006.01); C07D 215/42 (2006.01); C07D 215/48 (2006.01);
U.S. Cl.
CPC ...
C07D 215/42 (2013.01); A61K 47/545 (2017.08); A61K 47/6803 (2017.08); A61P 35/00 (2018.01); C07D 215/48 (2013.01);
Abstract

Disclosed are compounds having the formula (I): wherein Rrepresents a group: —NH, —NHCOR, —NHCOOR, —(C-C)alkenylene-CO—NH—OH, —(C-C)alkynylene-CO—NH—OH or —OH; Rrepresents a group: —OCH, —OCHCH, —SCH, —SCHCHor —OCHF; Rrepresents a hydrogen atom or a group: —CH, —CN, —F, —Cl or —OR; Rrepresents a hydrogen atom or a group: —CH, —CN, —F, —Cl or —OR; Rrepresents a group: —(C-C)alkyl or —CF; Rrepresents a group: —(C-C)alkyl or —CF; Rrepresents a group: —(C-C)alkyl or —CF; and Rrepresents a group: —(C-C)alkyl or —CF; in the state of a base or acid or acid salts or base salts or in the form of hydrate or of solvate. Also disclosed are drug conjugates including such compounds.


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