The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2024
Filed:
Jun. 06, 2022
Novartis Ag, Basel, CH;
Anthony Edward Boitano, Waban, MA (US);
Matthew Burger, Belmont, MA (US);
Susan E. Cellitti, San Diego, CA (US);
Michael P. Cooke, Boston, MA (US);
Catrin Finner, Neuried, DE;
Bernhard Hubert Geierstanger, Solano Beach, CA (US);
Yunho Jin, San Diego, CA (US);
Si Tuen Lee-Hoeflich, Lexington, MA (US);
HongNgoc Thi Pham, San Mateo, CA (US);
Siew Ho Schleyer, El Cerrito, CA (US);
Kathrin Tissot, Neuried, DE;
Tetsuo Uno, San Diego, CA (US);
Ben Wen, Encinitas, CA (US);
Novartis AG, Basel, CH;
Abstract
The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.