The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2024
Filed:
Jul. 27, 2018
Applicant:
Geron Corporation, Foster City, CA (US);
Inventors:
Aleksandra Rizo, Mount Kisco, NY (US);
Jacqueline Cirillo Bussolari, Skillman, NJ (US);
Assignee:
Geron Corporation, Foster City, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7125 (2006.01); A61K 9/00 (2006.01); A61K 47/54 (2017.01); A61P 7/00 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 31/7125 (2013.01); A61K 9/0019 (2013.01); A61K 47/543 (2017.08); A61P 7/00 (2018.01); C12N 15/1137 (2013.01);
Abstract
This disclosure provides methods of treating a myelodysplastic syndrome (MDS) in a subject that is naive to treatment with an agent selected from a hypomethylating agent (HMA) and lenalidomide, or both. The method includes administering to the subject an effective amount of a telomerase inhibitor, such as e.g. imetelstat or imetelstat sodium. In some cases, the subject treated is classified as low or intermediate-1 IPSS risk MDS and/or have MDS relapsed/refractory to Erythropoiesis-Stimulating Agent (ESA).