The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2024
Filed:
Feb. 27, 2021
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Haibo Qiu, Hartsdale, NY (US);
Rosalynn Molden, Shoreline, WA (US);
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/543 (2006.01); A61K 38/46 (2006.01); A61K 47/26 (2006.01); G01N 21/64 (2006.01); G01N 30/72 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54306 (2013.01); A61K 38/465 (2013.01); A61K 47/26 (2013.01); G01N 21/6428 (2013.01); G01N 30/7233 (2013.01); G01N 30/7266 (2013.01); G01N 33/6848 (2013.01); C12Y 301/01001 (2013.01);
Abstract
The present application provides methods and systems for identifying host cell protein impurities which have enzymatic activities in biopharmaceutical products and in samples during manufacturing processes. The present application provides various activity-based probes to characterize different enzyme classes of host cell protein impurities including probes containing functionalized molecules with reporter or affinity-based tags.