The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2024
Filed:
Feb. 21, 2017
Cytiva Sweden Ab, Uppsala, SE;
Klaus Gebauer, Uppsala, SE;
Sudheer Mygapula, Bangalore, IN;
Nachiket Karmarkar, Bangalore, IN;
Sasikumar Arumugam, Bangalore, IN;
Bashkar Hv, Bangalore, IN;
Ajit S. Vernekar, Bangalore, IN;
Nityananda Maiya, Bangalore, IN;
Prashanth Hosabettu Mohan, Bangalore, IN;
Sasi Kumar Nutalapati, Bangalore, IN;
Sameera Simha Hindupur, Bangalore, IN;
Shashidhar Hedge, Bangalore, IN;
Cytiva Sweden AB, Uppsala, SE;
Abstract
The invention discloses a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump () fluidically connected via a retentate compartment () of a crossflow filter () and a length of flexible tubing to a regulator valve (1; 101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve. The apparatus further comprises a first pressure transducer () adapted to measure a pressure between the retentate compartment and the regulator valve, a second pressure transducer () adapted to measure a pressure between the pump and the retentate compartment and a third pressure transducer () adapted to measure a pressure at a permeate outlet () of the crossflow filter, and a control unit () electrically or electromagnetically connected to said regulator valve, the first, second and third pressure transducers and optionally to the pump; b) pumping a liquid with the pump via the second pressure transducer, through the retentate compartment via the length of flexible tubing, the first pressure transducer and the regulator valve; c) controlling the regulator valve with the control unit, such that a TMP calculated by formula (I) TMP=(P+P)/2−Pcorresponds to a predetermined TMP value or to an interval between two predetermined TMP values, wherein Pis a pressure reading from the second pressure transducer, Pis a pressure reading from the first pressure transducer and Pis a pressure reading from the third pressure transducer.