The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2024
Filed:
Nov. 06, 2019
Applicant:
Richter Gedeon Nyrt., Budapest, HU;
Inventors:
László Párta, Saint-Louis, FR;
Ákos Putics, Budapest, HU;
Tibor Balogh, Budapest, HU;
Balázs Horváth, Ajka, HU;
Gáspár Nagy, Gyömr, HU;
Assignee:
RICHTER GEDEON NYRT., Budapest, HU;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C12P 21/005 (2013.01); C12N 5/0043 (2013.01); C12N 2500/20 (2013.01); C12N 2500/33 (2013.01); C12N 2500/34 (2013.01); C12N 2511/00 (2013.01);
Abstract
The present invention relates to a method for modifying the glycosylation profile of a recombinant glycoprotein produced in cell culture comprising culturing eukaryotic cells expressing the recombinant glycoprotein in a cell culture medium, wherein the cell culture medium is supplemented with fucose, manganese, and taurine, wherein the glycosylation profile of the produced recombinant glycoprotein is modified to better resemble the glycosylation profile of a reference glycoprotein than when cultured without said supplementation.