The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2024
Filed:
Dec. 06, 2019
Applicants:
Kirin Holdings Kabushiki Kaisha, Tokyo, JP;
Kyoto University, Kyoto, JP;
Inventors:
Shinichiro Takayanagi, Tokyo, JP;
Atsushi Kunisato, Tokyo, JP;
Sayaka Chuganji, Tokyo, JP;
Ken Fukumoto, Tokyo, JP;
Kazuki Nakazono, Tokyo, JP;
Shin Kaneko, Kyoto, JP;
Yohei Kawai, Kyoto, JP;
Assignees:
KIRIN HOLDINGS KABUSHIKI KAISHA, Tokyo, JP;
Kyoto University, Kyoto, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); C07D 215/00 (2006.01); C07D 217/22 (2006.01); C07D 471/18 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0646 (2013.01); C07D 215/00 (2013.01); C07D 217/22 (2013.01); C07D 471/18 (2013.01); C12N 5/0637 (2013.01); C12N 2501/48 (2013.01); C12N 2501/999 (2013.01);
Abstract
The present invention relates to a method for producing T cells or NK cells including culturing T cells or NK cells in a culture medium containing a CaMKII inhibitor such as a bisbenzylisoquinoline alkaloid compound. The disclosed compounds and methods can be used for maintaining the undifferentiated state of undifferentiated T cells, or for efficiently proliferating T cells or NK cells.