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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12168681 B1

PDFFull Text
Date of Patent:
Dec. 17, 2024

Filed:

Oct. 25, 2023

Il-2 variants with reduced binding to il-2 receptor alpha and uses thereof

Applicant:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Inventors:

Jiaxi Wu, Pleasantville, NY (US);

Tong Zhang, New Rochelle, NY (US);

Samuel Davis, New York, NY (US);

Nicolin Bloch, Ossining, NY (US);

Assignee:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Attorneys:

Fox Rothschild LLP

Aparna G. Patankar

Primary Examiner:

Jeffrey Stucker

Assistant Examiner:

Brittney E Donoghue

Int. Cl.
CPC ...
C07K 14/55 (2006.01); A61K 38/00 (2006.01); A61K 38/20 (2006.01); A61K 45/06 (2006.01); C07K 14/47 (2006.01); C07K 14/735 (2006.01); C07K 14/74 (2006.01);
U.S. Cl.
CPC ...
C07K 14/55 (2013.01); A61K 38/2013 (2013.01); A61K 45/06 (2013.01); C07K 14/4748 (2013.01); C07K 14/70535 (2013.01); C07K 14/70539 (2013.01); A61K 38/00 (2013.01); C07K 2319/21 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C07K 2319/41 (2013.01);
Abstract

This disclosure relates to IL-2 variants and methods of use thereof, including methods of treating or inhibiting a cancer or tumor. The IL-2 variants may have reduced ability in binding to or activating IL-2Rα. The IL-2 variants may retain the ability in binding to or activating IL-2Rβ and/or IL-2Rγ. In addition, the IL-2 variants may have decreased Treg activity but maintain the capacity to activate NK cells and T effector cells.

Find Patent Forward Citations

Wu, Jiaxi. (2024). Il-2 variants with reduced binding to il-2 receptor alpha and uses thereof (U.S. Patent No. 12168681). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12168681

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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