The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 17, 2024

Filed:

Jun. 25, 2021
Applicants:

Intocell, Inc., Daejeon, KR;

Y-biologics Inc., Daejeon, KR;

Inventors:

Taekyo Park, Daejeon, KR;

Sunyoung Kim, Daejeon, KR;

Suho Park, Daejeon, KR;

Doohwan Jung, Daejeon, KR;

Donghoon Seo, Daejeon, KR;

Sangkwang Lee, Daejeon, KR;

Sanghyeon Yun, Daejeon, KR;

Jihyeon Ha, Daejeon, KR;

Hyang Sook Lee, Daejeon, KR;

Okku Park, Daejeon, KR;

Beomseok Seo, Daejeon, KR;

Sena Kim, Daejeon, KR;

Minah Seol, Daejeon, KR;

Jina Song, Daejeon, KR;

Sung Ho Woo, Daejeon, KR;

Jongun Cho, Daejeon, KR;

Jaeho Lee, Sejong-Si, KR;

Hyun Mi Lee, Daejeon, KR;

Jae Eun Park, Daejeon, KR;

Youngja Song, Daejeon, KR;

Eunjin Lee, Daejeon, KR;

Hyun Ju Lee, Daejeon, KR;

Eun-Young Shim, Daejeon, KR;

Yunjung Ko, Daejeon, KR;

Minju Lee, Daejeon, KR;

Young woo Park, Daejeon, KR;

Yosup Rew, Daejeon, KR;

Assignees:

IntoCell, Inc., Daejeon, KR;

Y-Biologics Inc., Daejeon, KR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6849 (2017.08); A61K 47/6813 (2017.08); A61K 47/6817 (2017.08); A61K 47/6851 (2017.08); C07K 16/2827 (2013.01);
Abstract

The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.


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