The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2024
Filed:
Jun. 26, 2020
Applicants:
Massachusetts Institute of Technology, Cambridge, MA (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Inventors:
Ronald Raines, Cambridge, MA (US);
Ian Windsor, Brighton, MA (US);
Assignees:
Massachusetts Institute of Technology, Cambridge, MA (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); A61K 38/55 (2006.01);
U.S. Cl.
CPC ...
A61K 38/55 (2013.01); C12N 9/22 (2013.01);
Abstract
Disclosed herein are circular zymogens of RNase 1 that have a proteolytic cleavage site and are activated by a specific protease. These circular zymogens are useful for treatment of disorders that are characterized by a specific protease (e.g., HTV-1 protease).