The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2024
Filed:
Sep. 24, 2020
Applicant:
University Hospitals Cleveland Medical Center, Cleveland, OH (US);
Inventor:
Jordan M. Winter, Shaker Heights, OH (US);
Assignee:
UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER, Cleveland, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/444 (2006.01); A61P 35/00 (2006.01); G01N 33/50 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/444 (2013.01); A61P 35/00 (2018.01); G01N 33/5038 (2013.01); A61K 45/06 (2013.01);
Abstract
The invention provides methods of treating cancer characterized by the presence of one or both of wild type isocitrate dehydrogenase 1 (IDH1) gene and wild type IDH1 enzyme, by administering compounds that inhibit mutant IDH1 enzyme, such as Ivosidenib (AG-120, IVOSIDENIB®). The invention also provides cell-based methods for determining anti-cancer activity of test compounds under in vitro conditions of low concentrations of magnesium ion and/or glucose.