The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 10, 2024

Filed:

Sep. 26, 2022
Applicant:

Life Technologies Corporation, Carlsbad, CA (US);

Inventors:

Stephen P. Hendricks, Los Gatos, CA (US);

Michael Phelan, Millbrae, CA (US);

Marian Peris, San Mateo, CA (US);

Cheng-Yao Chen, San Diego, CA (US);

Daniel Mazur, San Diego, CA (US);

Xinzhan Peng, Carlsbad, CA (US);

Amy Castillo, Houston, TX (US);

Assignee:

Life Technologies Corporation, Carlsbad, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C07H 19/20 (2006.01); C12N 9/96 (2006.01); C12Q 1/6818 (2018.01); C12Q 1/6869 (2018.01); G01N 21/64 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6869 (2013.01); C07H 19/20 (2013.01); C12N 9/1241 (2013.01); C12N 9/1252 (2013.01); C12N 9/96 (2013.01); C12Q 1/6818 (2013.01); C12Y 207/07007 (2013.01); G01N 21/6428 (2013.01); G01N 33/582 (2013.01); C12Y 207/07 (2013.01); G01N 2021/6432 (2013.01);
Abstract

Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.


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