The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2024
Filed:
Aug. 21, 2020
Ohio State Innovation Foundation, Columbus, OH (US);
Ahmed Yousef, Dublin, OH (US);
David Kasler, Ashville, OH (US);
Emily Campbell, New Albany, OH (US);
Ohio State Innovation Foundation, Columbus, OH (US);
Abstract
An apparatus produces a target metabolite in a bioreaction. The apparatus has a reactor vessel that contains a bulk liquor in which the bioreaction is conducted, with a headspace provided above the bulk liquor. In some instances, the target metabolite is favorably partitioned into a foam formed at an interface of the bulk liquor and the headspace. A foam collector is arranged to receive this foam from the bioreactor and break it into a condensed foam liquid, from which the target metabolite may be isolated and purified. In one exemplary application, paenibacillin is produced by fermentation of a medium byOSY-DF, and is preferentially concentrated in the foam. In another exemplary application, fermentation of a medium byGF610 produces amyloliquecidin GF610 is which is preferentially concentrated in the foam.