The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2024
Filed:
Jun. 04, 2019
Applicant:
Howard Hughes Medical Institute, Chevy Chase, MD (US);
Inventors:
Jennifer Brown, Ashburn, VA (US);
Reza Behnam, Ashburn, VA (US);
Luke Coddington, Ashburn, VA (US);
Dougal Gowanlock Robinson Tervo, Ashburn, VA (US);
Joshua Dudman, Leesburg, VA (US);
Alla Karpova, Ashburn, VA (US);
Assignee:
Howard Hughes Medical Institute, Chevy Chase, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); C12N 15/86 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C12N 2750/14143 (2013.01);
Abstract
This document provides methods and materials for modulating one or more properties of transporter proteins. For example, inverted transporter polypeptides including a leader sequence fused to a transporter protein, and methods of using one or more inverted transporter polypeptides to modulate (e.g., stimulate or inhibit) the excitability of one or more cells (e.g., neurons and myocytes) are provided.