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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12162920 B1

PDFFull Text
Date of Patent:
Dec. 10, 2024

Filed:

Dec. 06, 2018

Hinge area and use of same in constructing car skeleton

Applicant:

Chongqing Precision Biotech Company Limited, Chongqing, CN;

Inventors:

Wei Zhang, Chongqing, CN;

JuanJuan Shan, Chongqing, CN;

WenXu Zhao, Chongqing, CN;

Jun Chen, Chongqing, CN;

Xia Huang, Chongqing, CN;

YongChun Zhao, Chongqing, CN;

YanMin Xu, Chongqing, CN;

QianZhen Zhang, Chongqing, CN;

Assignee:

CHONGQING PRECISION BIOTECH COMPANY LIMITED, Chongqing, CN;

Attorneys:

JCIP

Joseph G. Chu

Primary Examiner:

Julie Wu

Assistant Examiner:

Francesca Edgingtongiordan

Int. Cl.
CPC ...
C07K 14/705 (2006.01); A61K 39/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/464493 (2023.05); C12N 15/86 (2013.01); A61K 2239/17 (2023.05); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/58 (2023.05); C07K 2317/53 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01);
Abstract

Provided in the present invention are an improved hinge area and the use of same in constructing CAR skeleton. The amino acid sequence of the improved hinge area is as shown in SEQ ID NO.1 or SEQ ID NO.2 or SEQ ID NO.3, and the hinge area can prolong the survival of CAR-T cells in vivo and/or improve the capability of CAR-T cells to infiltrate tumors.

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Zhang, Wei. (2024). Hinge area and use of same in constructing car skeleton (U.S. Patent No. 12162920). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12162920

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