The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2024
Filed:
Oct. 21, 2019
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
New York University, New York, NY (US);
Genoveffa Franchini, Washington, DC (US);
Timothy Cardozo, New York, NY (US);
Manuel Becerra-Flores, Brooklyn, NY (US);
Isabela Silva de Castro, Bethesda, MD (US);
Giacomo Gorini, Bethesda, MD (US);
Massimiliano Bissa, Washington, DC (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
New York University, New York, NY (US);
Abstract
Embodiments of recombinant HIV-1 gp120 proteins that contain a V1 deletion are disclosed. Also provided are gp140, gp145, and gp160 proteins containing the V1 deletion, as well as HIV-1 Env ectodomain trimers containing protomers containing the V1 deletion. Nucleic acid molecules encoding these proteins are also provided. In several embodiments, the disclosed recombinant HIV-1 proteins and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.