The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 10, 2024

Filed:

Apr. 21, 2020
Applicants:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

Merck Sharp & Dohme (Uk) Limited, London, GB;

Inventors:

John Y. L. Chung, Staten Island, NY (US);

Tetsuji Itoh, Somerset, NJ (US);

Jungchul Kim, Basking Ridge, NJ (US);

Jacob Henry Waldman, Metuchen, NJ (US);

Debra J. Wallace, Lexington, MA (US);

Andrew Wood, Brookline, MA (US);

Feng Xu, Staten Island, NY (US);

Andrew Gibson, Welwyn Garden City, GB;

Jeremy Peter Scott, Hertford, GB;

Assignees:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Merck Sharp & Dohme (UK), London, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/08 (2006.01); C07D 211/96 (2006.01);
U.S. Cl.
CPC ...
C07D 471/08 (2013.01); C07D 211/96 (2013.01);
Abstract

The invention is related to the preparation of protected piperidine carboxylates suitable for use as intermediates that lead, via a series of additional process steps, including a sulfation of a hydroxy urea compound, to the preparation of the beta lactamase inhibitor (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide.


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