The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 10, 2024

Filed:

Jan. 27, 2021
Applicant:

Hinova Pharmaceuticals Inc., Sichuan, CN;

Inventors:

Lei Fan, Sichuan, CN;

Fei Wang, Sichuan, CN;

Xiaoquan Wu, Sichuan, CN;

Kexin Xu, Sichuan, CN;

Ke Chen, Sichuan, CN;

Tongchuan Luo, Sichuan, CN;

Shaohua Zhang, Sichuan, CN;

Yongxu Huo, Sichuan, CN;

Zhilin Tu, Sichuan, CN;

Xinghai Li, Sichuan, CN;

Yuanwei Chen, Sichuan, CN;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 45/06 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 45/06 (2013.01); C07D 519/00 (2013.01);
Abstract

The compound of formula (I) has a good inhibitory effect on the proliferation of human prostate cancer cells CWR22RV1 and breast cancer cells; and combined use of the compound with an androgen receptor inhibitor HC-1119 significantly enhances the inhibitory effect on prostate cancer cells, and the inhibitory effect increases with increased concentration. The compound of formula (I) can not only be used independently to prepare an antineoplastic agent but can also be used in combination with other agents having antineoplastic effects, such as an androgen receptor inhibitor, or other targeting drugs etc., to prepare an antineoplastic agent having stronger therapeutic effects, especially an agent for treating prostate cancer and breast cancer.


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