The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2024
Filed:
Sep. 19, 2019
Shanghai University of Medicine&health Sciences, Shanghai, CN;
Gang Huang, Shanghai, CN;
Bin Li, Shanghai, CN;
SHANGHAI UNIVERSITY OF MEDICINE & HEALTH SCIENCES, Shanghai, CN;
Abstract
The invention relates to a radioactive I-labeled Larotrectinib compound and a preparation method and application thereof, including a radioactive I-labeled Larotrectinib compound having the following structural formula and its analogs: where Rand Rare respectively H, F, Cl, Br,I,I,I,I orI, and at least one of Rand Ris a radioactive iodine element. The invention provides a preparation method of a radioiodinated pyrazolo[1,5-]pyrimidine compound base. Radioiodinated pyrazolo[1,5-]pyrimidine compounds with long half-life and different ray energy can be used for PET tomography and clinical diagnostic research of SPECT. Moreover, the high-energy radioiodinated pyrazolo[1,5-]pyrimidine can act as a TrK receptor ligand to inhibit the activity of TRK and kill tumor cells; and due to high-energy I-131 ray energy carried, the radioiodinated pyrazolo[1,5-]pyrimidine can coordinate to shoot tumor cells and thus achieve an accurate radiotherapy effect.