The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2024
Filed:
Jun. 17, 2021
Takeda Pharmaceutical Company Limited, Osaka, JP;
Farah Natoli, Georgetown, MA (US);
Gaozhong Zhu, Weston, MA (US);
Jennifer Terew, Concord, MA (US);
Yuan Jiang, Londonderry, NH (US);
Jamie Tsung, Wellesley, MA (US);
Zahra Shahrokh, Weston, MA (US);
Brian Vernaglia, Winchester, MA (US);
Jing Pan, Boxborogh, MA (US);
Richard Pfeifer, North Granby, CT (US);
Pericles Calias, Melrose, MA (US);
Takeda Pharmaceutical Company Limited, Osaka, JP;
Abstract
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising a heparan N-sulfatase (HNS) protein, salt, and a polysorbate surfactant for the treatment of Sanfilippo Syndrome Type A.