The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2024
Filed:
May. 18, 2018
Applicant:
Umc Utrecht Holding B.v., Utrecht, NL;
Inventors:
Jürgen Herbert Ernst Kuball, Utrecht, NL;
Zsolt Sebestyen, Utrecht, NL;
Dennis Beringer, Utrecht, NL;
Anna Vyborova, Utrecht, NL;
Assignee:
UMC UTRECHT HOLDING B.V., Utrecht, NL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61K 38/17 (2006.01); A61P 35/00 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 38/1774 (2013.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 16/2827 (2013.01); C07K 2319/00 (2013.01);
Abstract
The current disclosure provides polypeptide constructs and cells comprising CDR3 regions of γ9. δ2 or both, that selectively bind a J-configuration of CD277 on a target cell. The disclosure also provides pharmaceutical compositions with the disclosed polypeptides or cells and methods of using these compositions in the treatment of cancer.