The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2024
Filed:
Oct. 09, 2019
The Regents of the University of California, Oakland, CA (US);
Novartis Ag, Basel, CH;
Jessica Spradlin, Berkeley, CA (US);
Carl C. Ward, Berkeley, CA (US);
Daniel K. Nomura, Walnut Creek, CA (US);
Markus Schirle, Cambridge, MA (US);
John A. Tallarico, Cambridge, MA (US);
Jeffrey McKenna, Cambridge, MA (US);
Thomas John Maimone, Richmond, CA (US);
Xirui Hu, Cambridge, MA (US);
The Regents of the University of California, Oakland, CA (US);
Novartis AG, Basel, CH;
Abstract
Disclosed herein, inter alia, are compositions and methods for targeting E3 ligases. In an aspect is a targeted protein degrader including 1) a targeted protein binder and 2) an E3 Ubiquitin ligase binder, wherein the E3 Ubiquitin ligase is human RNF4 or human RNF114. In an aspect is provided a pharmaceutical composition including a compound as described herein, including embodiments, and a pharmaceutically acceptable excipient.