The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 03, 2024

Filed:

Sep. 21, 2023
Applicant:

Roche Sequencing Solutions, Inc., Pleasanton, CA (US);

Inventors:

Roger J. A. Chen, Saratoga, CA (US);

Randall Davis, Pleasanton, CA (US);

Assignee:

Roche Sequencing Solutions, Inc., Pleasanton, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/487 (2006.01); B81B 1/00 (2006.01); G01N 15/12 (2024.01); G01N 15/13 (2024.01); G01N 33/483 (2006.01); B82Y 5/00 (2011.01); C12Q 1/6869 (2018.01);
U.S. Cl.
CPC ...
G01N 33/48721 (2013.01); B81B 1/00 (2013.01); G01N 15/12 (2013.01); G01N 15/13 (2024.01); G01N 33/483 (2013.01); B82Y 5/00 (2013.01); C12Q 1/6869 (2013.01);
Abstract

A method of forming a nanopore in a lipid bilayer is disclosed. A nanopore forming solution is deposited over a lipid bilayer. The nanopore forming solution has a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed un-stimulated in the lipid bilayer. Formation of a nanopore in the lipid bilayer is initiated by applying an agitation stimulus level to the lipid bilayer. In some embodiments, the concentration level and the corresponding activity level of pore molecules are at levels such that less than 30 percent of a plurality of available lipid bilayers have nanopores formed un-stimulated therein.


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