The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 03, 2024

Filed:

May. 06, 2021
Applicant:

Florida Atlantic University Board of Trustees, Boca Raton, FL (US);

Inventors:

E Du, Boca Raton, FL (US);

Yuhao Qiang, Boca Raton, FL (US);

Darryl Dieujuste, North Miami, FL (US);

Jia Liu, Boca Raton, FL (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); B01L 3/00 (2006.01); G01N 1/40 (2006.01); G01N 33/00 (2006.01); G01N 33/487 (2006.01); G01N 33/49 (2006.01);
U.S. Cl.
CPC ...
G01N 33/0022 (2013.01); B01L 3/502761 (2013.01); G01N 1/4077 (2013.01); G01N 33/48707 (2013.01); G01N 33/48728 (2013.01); G01N 33/491 (2013.01); G01N 33/6893 (2013.01); B01L 2300/0645 (2013.01); G01N 2001/4088 (2013.01); G01N 2800/224 (2013.01);
Abstract

An exemplary portable automated device is developed for in vitro testing of blood vascular occlusion as a result of sickle cell disease. The portable automated device may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable automated device, analysis may be performed on sickle cell samples on a microfluidic platform that mimics the structure of human capillaries. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.


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