The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2024
Filed:
Dec. 18, 2019
Aarhus Universitet, Aarhus C, DK;
Christian Kanstrup Holm, Lystrup, DK;
Yonglun Luo, Egå, DK;
Magnus Stougaard, Viby J, DK;
Charlotte Thornild Møller, Lystrup, DK;
Mette Nyegaard, Gistrup, DK;
Aarhus Universitet, Aarhus, DK;
Abstract
The present invention relates to a composition comprising a first gRNA bound to an RNA-guided endonuclease forming a first ribonucleoprotein complex, said first gRNA comprises a first targeting sequence being complementary for a first target sequence in an intron in the 5' upstream part of a fusion gene; and a second gRNA bound to an RNA-guided endonuclease forming a second ribonucleoprotein complex, said second gRNA comprises a second targeting sequence being complementary for second target sequence in an intron in the 3′ downstream part of the fusion gene. Such compositions may find use in the treatment of fusion gene related cancers.