The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2024
Filed:
May. 02, 2023
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Inventors:
Christian S. Hinrichs, Princeton, NJ (US);
Benjamin Y. Jin, Bethesda, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/867 (2006.01); A61K 39/00 (2006.01); C07K 14/54 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/4632 (2023.05); A61K 39/46444 (2023.05); A61K 39/464491 (2023.05); A61K 39/464838 (2023.05); C07K 14/5443 (2013.01); C12N 15/62 (2013.01); C12N 15/867 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/59 (2023.05); C07K 2319/03 (2013.01);
Abstract
Disclosed are nucleic acids and polypeptides which provide the co-expression of interleukin (IL)-21 and IL-15 by a host cell, each interleukin being bound to the cell membrane by a cell membrane anchor moiety. Also disclosed are related recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.