The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2024
Filed:
Nov. 19, 2019
Applicants:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Voronoi Inc, Incheon, KR;
Inventors:
Assignees:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Voronoi Inc., Incheon, KR;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/22 (2006.01); C07D 471/22 (2006.01);
U.S. Cl.
CPC ...
C07D 487/22 (2013.01); C07D 471/22 (2013.01);
Abstract
Disclosed are macrocyclic compounds that possess inhibitory activity against DYRK, TRK, TLK, and/or RET. Also disclosed are pharmaceutical compositions containing the compounds, methods of making the compounds, and methods of using the compounds to treat diseases and disorders that are characterized or mediated by aberrant DYRK, TRK, TLK, and/or RET activity such as cancer, neurodegenerative disorders and genetic disorders.