The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2024
Filed:
Mar. 05, 2021
Applicant:
Sanofi, Paris, FR;
Inventors:
Assignee:
SANOFI, Paris, FR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/12 (2006.01); B01J 31/16 (2006.01); C07C 55/07 (2006.01); C07C 59/255 (2006.01);
U.S. Cl.
CPC ...
C07D 207/12 (2013.01); B01J 31/1616 (2013.01); C07C 55/07 (2013.01); C07C 59/255 (2013.01);
Abstract
Herein is provided a novel process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylate by a Suzuki coupling of compound (3), wherein LG represents a leaving group, with an organoboron reagent: Compound (3) is obtained by activation of compound (4) with a leaving group LG, and compound (4) is obtained by alpha-arylation of methyl 5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-carboxylate with 1-LG'-2,4-dichlorobenzene, wherein LG′ represents a leaving group: