The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 03, 2024

Filed:

Sep. 15, 2021
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Peter J. McDonnell, Baltimore, MD (US);

Yasin A. Khan, Baltimore, MD (US);

Samuel K. Lai, Chapel Hill, NC (US);

Renata T. Kashiwabuchi, Baltimore, MD (US);

Ashley Behrens, Baltimore, MD (US);

Justin S. Hanes, Baltimore, MD (US);

Assignee:

THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/16 (2006.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01); A61K 31/519 (2006.01); A61K 31/52 (2006.01); A61K 45/06 (2006.01); A61K 47/58 (2017.01); A61K 47/60 (2017.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
A61K 9/1676 (2013.01); A61K 9/0048 (2013.01); A61K 9/0051 (2013.01); A61K 9/1641 (2013.01); A61K 9/1647 (2013.01); A61K 9/5026 (2013.01); A61K 9/5031 (2013.01); A61K 9/5146 (2013.01); A61K 9/5153 (2013.01); A61K 31/519 (2013.01); A61K 31/52 (2013.01); A61K 45/06 (2013.01); A61K 47/58 (2017.08); A61K 47/60 (2017.08); A61K 47/6921 (2017.08); A61K 47/6931 (2017.08);
Abstract

Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or TOP after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.


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