The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2024
Filed:
Nov. 08, 2023
Applicant:
Arvinas Operations, Inc., New Haven, CT (US);
Inventor:
Keith R. Hornberger, Southbury, CT (US);
Assignee:
Arvinas Operations, Inc., New Haven, CT (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/55 (2017.01); A61K 47/54 (2017.01);
U.S. Cl.
CPC ...
A61K 47/55 (2017.08); A61K 47/545 (2017.08);
Abstract
Provided herein are bifunctional compounds having the chemical structure I:PTM-L-CLM (I);or pharmaceutically acceptable salts thereof, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (Raf, such as c-Raf, A-Raf, and/or B-RAF) and are useful in the treatment of a variety of Raf mediated conditions or diseases, such as cancer, specifically lung cancer, skin cancer, or colorectal cancer.