The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 03, 2024

Filed:

Feb. 21, 2020
Applicant:

City of Hope, Duarte, CA (US);

Inventors:

Javier Gordon Ogembo, Duarte, CA (US);

Lorraine Zvichapera Mutsvunguma, Duarte, CA (US);

David H. Mulama, Duarte, CA (US);

Murali Muniraju, Duarte, CA (US);

Felix Wussow, Monrovia, CA (US);

Assignee:

CITY OF HOPE, Duarte, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/245 (2006.01); A61K 39/00 (2006.01); A61K 39/17 (2006.01); A61P 31/22 (2006.01); C07K 14/005 (2006.01);
U.S. Cl.
CPC ...
A61K 39/245 (2013.01); A61K 39/17 (2013.01); A61P 31/22 (2018.01); C07K 14/005 (2013.01); A61K 2039/5258 (2013.01); C12N 2710/16423 (2013.01); C12N 2710/16434 (2013.01); C12N 2760/18134 (2013.01);
Abstract

Vaccine compositions comprising a single KSHV-LP comprising two or more KSHV glycoproteins and/or one or more T cell antigens and methods of preventing or treating KSHV infections using the vaccine compositions. An expression system or a single expression vector for co-expressing two or more KSHV glycoproteins simultaneously to generate a vaccine comprising a single virus-like particle. The expression system may include a single plasmid inserted with two or more nucleic acid sequences that encode two or more KSHV glycoproteins linked by one or more linking sequences such that the KSHV glycoproteins are co-expressed simultaneously.


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