The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2024
Filed:
Jan. 18, 2019
Fundação Oswaldo Cruz, Manguinhos, BR;
Tatiana De Arruda Campos Brasil De Souza, Curitiba, BR;
Nilson Ivo Tonin Zanchin, Curitiba, BR;
Stephanie Bath De Morais, Curitiba, BR;
FUNDAÇÃO OSWALDO CRUZ, Rio de Janeiro, BR;
Abstract
The present invention refers to polypeptides with asparaginase activity that have an increased rate of self-processing compared to human wild L-asparaginase (ASRGLI), resulting from a mutation in the ASRGLI glycine rich loop called HGG loop (Histidine 8-Glycine 9-Glycine 10). Polynucleotides that encode the polypeptides of invention are also described herein. Expression cassettes comprising said polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the invention polypeptide in the manufacture of a preventive medicine or cancer treatment and methods to produce the polypeptide of invention and to prevent or treat cancer are also described.