The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2024
Filed:
Jan. 15, 2021
Applicant:
Rutgers, the State University of New Jersey, New Brunswick, NJ (US);
Inventors:
Yufang Shi, Belle Mead, NJ (US);
Guangwen Ren, Bar Harbor, ME (US);
Liying Zhang, Belle Mead, NJ (US);
Assignee:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, New Brunswick, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/28 (2015.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 38/21 (2006.01); A61P 37/04 (2006.01); A61P 37/06 (2006.01); C12N 5/00 (2006.01); C12N 5/074 (2010.01); C12N 5/0775 (2010.01); A61K 35/12 (2015.01); A61K 45/06 (2006.01); A61P 37/02 (2006.01); C07K 14/495 (2006.01); C07K 14/50 (2006.01); C07K 14/52 (2006.01); C07K 14/525 (2006.01); C07K 14/545 (2006.01); C07K 14/56 (2006.01); C07K 14/565 (2006.01); C07K 14/57 (2006.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A61K 38/1825 (2013.01); A61K 38/1841 (2013.01); A61K 38/191 (2013.01); A61K 38/20 (2013.01); A61K 38/2006 (2013.01); A61K 38/212 (2013.01); A61K 38/215 (2013.01); A61K 38/217 (2013.01); A61P 37/04 (2018.01); A61P 37/06 (2018.01); C12N 5/0018 (2013.01); C12N 5/0607 (2013.01); C12N 5/0662 (2013.01); C12N 5/0663 (2013.01); C12N 5/0665 (2013.01); A61K 2035/122 (2013.01); A61K 45/06 (2013.01); A61P 37/02 (2018.01); C07K 14/495 (2013.01); C07K 14/50 (2013.01); C07K 14/52 (2013.01); C07K 14/525 (2013.01); C07K 14/545 (2013.01); C07K 14/56 (2013.01); C07K 14/565 (2013.01); C07K 14/57 (2013.01); C12N 2500/05 (2013.01); C12N 2501/10 (2013.01); C12N 2501/115 (2013.01); C12N 2501/15 (2013.01); C12N 2501/2301 (2013.01); C12N 2501/2317 (2013.01); C12N 2501/24 (2013.01); C12N 2501/25 (2013.01); C12N 2502/1114 (2013.01);
Abstract
The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs).