The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2024
Filed:
Aug. 29, 2023
Ventana Medical Systems, Inc., Tucson, AZ (US);
Michael Barnes, San Francisco, CA (US);
Joerg Bredno, San Francisco, CA (US);
Rebecca C. Bowermaster, Oro Valley, AZ (US);
Srinivas Chukka, San Jose, CA (US);
Wen-Wei Liu, Tucson, AZ (US);
Kandavel Shanmugam, Oro Valley, AZ (US);
Junming Zhu, San Diego, CA (US);
Ventana Medical Systems, Inc., Tucson, AZ (US);
Abstract
Immune context scores are calculated for tumor tissue samples using continuous scoring functions. Feature metrics for at least one immune cell marker are calculated for a region or regions of interest, the feature metrics including at least a quantitative measure of human CD3 or total lymphocyte counts. A continuous scoring function is then applied to a feature vector including the feature metric and at least one additional metric related to an immunological biomarker, the output of which is an immune context score. The immune context score may then be plotted as a function of a diagnostic or treatment metric, such as a prognostic metric (e.g. overall survival, disease-specific survival, progression-free survival) or a predictive metric (e.g. likelihood of response to a particular treatment course). The immune context score may then be incorporated into diagnostic and/or treatment decisions.