The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2024
Filed:
Sep. 17, 2021
Q-state Biosciences, Inc., Cambridge, MA (US);
Graham T. Dempsey, Cambridge, MA (US);
Owen McManus, Belmont, MA (US);
Hongkang Zhang, Wellesley, MA (US);
David Gerber, Cambridge, MA (US);
Pin Liu, Cambridge, MA (US);
Dawei Zhang, Cambridge, MA (US);
Duncan Brown, Cambridge, MA (US);
Sudhir Agrawal, Cambridge, MA (US);
Caitlin Lewarch, Cambridge, MA (US);
QuellTx, Inc., Cambridge, MA (US);
Abstract
The invention provides non-opioid pain therapeutic compositions that include an antisense oligonucleotide (ASO) complementary to an identified target on a NaV channel mRNA. The ASO hybridizes to its target RNA and forms a duplex that recruits RNase H to degrade the RNA, thereby downregulating NaV channel synthesis, which inhibits the neuron's ability to contribute to the perception of pain. The ASO targets one of the specific identified targets, and may be provided as a gapmer that includes a central DNA segment flanked by modified RNA wings. When the composition is delivered to dorsal root ganglion (DRG) neurons in vitro, the DRG neurons exhibit a dose-dependent knockdown of NaV1.7, NaV1.8, or NaV1.9.